This causes it to heal very slowly. There are three types of cartilage: hyaline, fibrous, and elastic cartilage. The focus of most cartilage tissue engineering strategies has been on regenerating hyaline tissue and yet there is good reason to think that reconstruction of both the calciﬁed cartilage and lamina splendens will be necessary for long-term survival of implants. Elastic cartilage is springy, yellow, and elastic and is found in the internal support of the external ear and in the epiglottis. 2. Chondrification is the process by which cartilage is formed from condensed mesenchyme tissue. Biologydictionary.net Editors. Nuernberger S. Cyran N. Albrecht C. Redl H. Vécsei V. Marlovits S. The influence of scaffold architecture on chondrocyte distribution and behavior in matrix-associated chondrocyte transplantation grafts. The matrix is gelatinous and the cartilage would not remain in place, A thick layer would counteract the elasticity of the fibers, It would be unable to absorb enough nutrients, Noncollagenous proteins, collagen and proteoglycans, Proteoglycans monomers, hyaluronic acid and link proteins, A type of collagen only found in hyaline cartilage, A type of collagen only found in elastic cartilage, A type of collagen which attaches to another collagen fiber. They consist of translucent protoplasm in which fine interlacing filaments and minute granules are sometimes present. Fibril-associated collagen with interrupted triple helix (FACIT) is: Biologydictionary.net Editors. They are surrounded by the matrix and contained within allotted spaces called lacunae. It is the only type of cartilage that contains type I collagen in addition to the normal type II. The perichondrium is a dense layer of connective tissue which surrounds most cartilage sites. All forms of connective tissue are composed of (1) extracellular fibres, (2) an amorphous matrix called ground substance, and (3) stationary and migrating cells. These fibers are what allow the cartilage to retain the flexibility needed to coat joint endings and form structures such as the nose and ears. Embedded in this are one or two round nuclei with the usual intranuclear network. In certain situations, fibroblasts transform into chondrocytes. In “cell-scaffold construct” strategies, seed cells can be autologous chondrocytes or stem. Isolating chondrocytes from the joint surface is difficult, and would cause secondary injury leading to OA. As it wears away with age … In other regions it acts as a shock absorber, cushioning areas where bone meets bone and preventing abrasion and damage. The remodeling of cartilage is predominantly affected by changes and rearrangements of the collagen matrix in response to forces experienced by the cartilage. It owes its flexibility and toughness to the fibrous tissue, and its elasticity to the cartilaginous tissue. Compared to other connective tissues, cartilage has a very slow turnover of its extracellular matrix and is documented to repair at only a very slow rate relative to other tissues. The optimal cell source for cartilage tissue engineering is still being identified. Cartilage is a semi-rigid but flexible avascular connective tissue found at various sites within the body. In appositional growth, fresh layers of matrix are added to existing matrix surface by chondroblasts in the perichondrium. Articular cartilage function is dependent on the molecular composition of its ECM, which consists mainly of proteoglycans and collagens. Cartilage does continue to grow slowly, however. Unlike many other cells, cartilage cells are not connected to blood vessels. Can include both growth and remodeling of cartilage, called chondrocytes, the primary cell types in form! 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